Hey guys this is my system specs...
Mobo - Maximus formula motherboard
Gpu - Geforce 9800GTX OC'ed at 701/1153/2001
Cpu - Intel E8400 OC'ed at 4.0 Ghz
Ram - DDR2 800

Now i was wondering what the best plugin setup and settings would be for me? Any help at all would be great.

The settings are pretty generic, make sure you have all REC's enabled as well as Dual Core options in the CPU options. Use the latest build of GSDX as your GS plugin and use ZeroSPU for audio. Then theres some small tweaks depending on the game your playing.